博士

教授、博士生导师、主任药师

从事我国远海西沙群岛的海洋底栖动物海绵及其共生微生物药源分子的发现、海洋生物功能分子的规模化制备、结构优化、生物活性及作用机制研究。阐明了中国远海西沙海域海绵资源的化学结构多样性及其功能特点。构建了首个基于西沙特殊生境的海绵标本库和研究用样本库。采用HPLC-DAD分子指纹图谱示踪结合NMR谱学特征分析快速识别方法，从30余种西沙海绵中分离鉴定了具有化学他感效应的环肽、萜醌、聚酮、萜烯等特征结构1000余种，全新骨架化合物20个。通过多靶标活性筛选和构效关系研究，优选出10个强活性的新型抗肿瘤先导化合物（IC50达nM级）。阐明了B-5和B-6诱导肿瘤细胞凋亡、抑制细胞增殖和迁移的分子机制，发现B-5是首个作用于促凋亡蛋白puma的海洋分子。研制了3个作用机制明确、活性显著、安全性高的抗肿瘤候选药物，利用全合成方法解决了PK-13的药源问题。探索出一条“基于特殊生境海绵化学防御及共生体系的强活性抗肿瘤先导化合物的发现”的高效途径，推动了西沙海域海绵资源的深层开发。

上海交通大学医学院海洋药物重点实验室主任，癌基因与相关基因国家重点实验室PI；国家杰出青年科学基金、上海市优秀学科带头人、上海市科技启明星获得者。兼任中国海洋生物化学与分子生物学分会副理事长，上海市药学会常务理事，上海市海洋湖沼学会常务理事，上海市海洋药物专业委员会主任委员。

1. Piao, S.J., Jiao, W.H., Yang, F., Yi, Y.H., Di, Y.T., Han, B.N.,* Lin, H.W.* New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne. Mar. Drugs, 2014, 12(7): 4096-4109 2. Jiao, W.H., Xu, T.T., Yu, H.B., Mu, F.R., Li, J, Li, Y.S., Yang, F., Han,B.N., Lin, H.W.* Dysidaminones A-M, Cytotoxic and NF-κB InhibitorySesquiterpeneAminoquinones from the South China SeaSponge DysideafragilisRSC Advances, 4, 9236–9246（IF = 2.562） 3. Gan, J.H., Xu, C.H., Yu, H.B., Lin, H.W.*Zhou, Q., Sun, S.Q.* Rapid Discrimination of China Sponges by Tri-step Infrared Spectroscopy: A Preliminary Study. Journal of Molecular Structure，2014, 1069, 147–151 4. Jiao, W.H., Xu, T.T., Yu, H.B., Chen, G.D., Huang, X.J., Yang, F, Li, Y.S., Han, B.N., Liu, X.Y.* Lin, H.W. * Dysideanones AC, Unusual Sesquiterpene Quinones from the South China Sea Sponge Dysideaavara. Journal of Natural Products, 2014, 77 (2), 346–350 5. Piao, S.J., Song, Y.L., Jiao, W.H., Yang, F., Liu, X.F., Chen, W.S., Han, B.N., Lin, H.W. * Hippolachnin A, a New AntifungalPolyketide from the South China SeaSponge Hippospongialachne. Organic Letters, 2013, 15 (14): 3526-3529 (IF = 6.142) (IF = 6.142) 6. Yan, M., Zhu, Y., Zhang, H.J., Jiao, W.H., Han, B.N., Liu, Z.X., Qiu, F. * Chen, W.S., Lin, H.W.* Anti-inflammatory secondary metabolites from the leaves of Rosalaevigata. Bioorganic & Medicinal Chemistry, 2013, 21 (11): 3290–3297 (IF = 2.903) 7. Wang, Y.W., Zhang, J.B., Wang, Q.X., Zhang, T., Yang, Y., Yi, Y.H., Gao, G.X., Dong, H.J., Zhu, H.F., Li, Y., Lin, H.W.* Tang, H.F.* Chen, X.Q.* Bryostatin 5 induces apoptosis in acute monocytic leukemia cells by activating PUMA and caspases. European Journal of Pharmacology, 2013, 718: 340-349（IF=2.592） 8. Yang, F., Ji, R.H., Li, J., Gan, J.H., Lin, H.W.* N-Containing Metabolites from the Marine Sponge Agelasclathrodes. Natural Product Communications. 2013, 8 (12), 1713-1714 (IF = 0.956) 9. Xu, Y., Lang, J.H., Jiao, W.H., Wang, R.P., Peng, Y., Song, S.J.* Zhang, B.H.* Lin, H.W.* Formamido-Diterpenes from the South China Sea SpongeAcanthellacavernosa. Marine Drugs, 2012,10: 1445-1458 (IF = 3.978) 10. Yu, H.B., Liu, X.F., Xu, Y., Gan, J.H., Jiao, W.H., Lin, H.W.* Woodylides A‒C, Three New Cytotoxic secoPolyketides from the South China Sea Marine Sponge Plakortis simplex, Marine Drugs, 2012,10: 10271036 (IF = 3.978) 11. Liu, X.F.,Shen, Y.* Yang, F., Jiao, W.H., Zhang, H.J., Yu, H.B., Chen, W.S., Xiao, J.R., Lin, H.W.* Simplexolides A‒F and Plakorfuran A, Seven Butyrate Derived Polyketides from the Marine Sponge Plakortis simplex. Tetrahedron, 2012，68: 46354640(IF = 2.803) 12. Yang, F., Hamann, M.T., Zou, Y.K., Zhang, M.Y., Gong, X.B., Chen, W.S., Lin, H.W.* Antimicrobial Metabolites from the ParacelIslands sponge Agelasmauritiana. Journal of Natural Products, 2012，75 (4)：774–778(IF = 3.285) 13. Wang, R.P., Lin, H.W.* Li, L.Z., Gao, P.Y., Xu, Y., Song, S.J.*（共同通讯）.Monoindole alkaloids from a marine sponge Mycalefibrexilis. Biochemical Systematics and Ecology,2012, 43: 210-213(IF = 1.153) 14. Xu, Y., Song, Y.L., Li, N., Jiao, W.H., Wang, R.P., Peng, Y., Qi, S.H., Song, S.J. * Chen, W.S., Lin, H.W.* Antifouling and cytotoxic constituents from the South China Sea sponge Acanthellaconvernosa: absolute stereostructures of kalihinols M-T. Tetrahedron, 2012, 68: 28762883(IF = 2.803) 15. Han, M.Q., Liu, F., Zhang, F.L., Li, Z.Y. * Lin, H.W.* Bacterial and ArchaealSymbionts in the South China Sea Sponge Phakelliafusca: Community Structure, Relative Abundance and Ammonia-oxidizing Populations, Mar Biotechnol, 2012, 14:701–713(IF =2.739). 16. Jiao, W.H., Huang, X.J., Yang, J.S., Gao, H., Yang, F., Piao, S.J., Li, J., Ye, W.C., Yao, X.S., Chen, W.S., Lin, H.W.* Dysidavarones A-D, Novel Sesquiterpene Quinones from Marine SpongeDysideaavara. Organic Letters, 2012, 14 (1): 202205 (IF = 6.142) 17. Liu, X.F., Song, Y.L., Zhang, H.J., Yang, F., Yu, H.B., Jiao, W.H., Piao, S.J., Chen, W.S., Lin, H.W.* Simplextones A and B, Unusual Polyketides from the Marine Sponge Plakortis simplex. Organic Letters, 2011, 13 (12): 3154–3157 (IF = 5.862). 18. Piao, S.J., Zhang, H.J., Lu, H.Y., Yang, F., Jiao, W.H., Yi, Y.H., Chen, W.S., Lin, H.W.* Hippolides A–H, Acyclic Manoalide Derivatives from the Marine Sponge Hippospongialachne. Journal of Natural Products, 2011, 74 (5): 1248-1254 (IF = 3.128). 19. Zeng, N., Shen, Y.* Li, L.Z., Jiao, W.H., Gao, P.Y., Song, S.J., Chen, W.S., Lin, H.W.* Anti-inflammatory Triterpenes from the Leaves of Rosalaevigata.Journal of Natural Products, 2011, 74 (4): 732–738 (IF = 3.128). 20. Yang, F., Chen, J.T., Piao, S.J., Chen, W.S., Lin, H.W.* New cytotoxic oxygenated sterols from marine bryozoan Bugulaneritina. Natural Product Research,2011, 25(16):1505-11（IF=0.81）. 21. Chu, D., Peng, C.S., Ding, B., Liu, F., Zhang, F.L., Lin, H.W.* Li, Z.Y.* Biological active metabolite cyclo (L-Trp-L-Phe) produced by South China Sea sponge Holoxea sp. Associated fungus Aspergillusversicolor strain TS08. Bioprocess and Biosystems Engineering, 2010, 34 (2):223-9（IF=1.823）. 22. Zhang, H.J., Yi, Y.H., Yang, G.J., Hu, M.Y., Cao, G.D., Yang, F., Lin, H.W.* Proline-Containing Cyclopeptides from the Marine Sponge Phakelliafusca. Journal of Natural Products, 2010,73 (4)：650–655（IF = 3.159）. 23. Tang, H., Wang, Z.L., Cheng, P., Piao, S.J., Chen, W.S., Lin, H.W.* Hai-Feng Tang. Steroids from the marine bryozoan Bugulaneritina. Chemistry of Natural Compounds, 2010, 46 (3): 330-332（IF=0.572）. 24. Zhang, H.J., Yi, Y.H., Lin, H.W.* Oxygenated 4-Methylene Sterols from the South China Sea Sponge Theonellaswinhoei. Helvetica ChimicaActa,2010, 93, 1120-1126（IF=1.435）. 25. Gao, P.Y., Li, L.Z., Peng, Y., Piao, S.J., Zeng, N., Lin, H.W.* Song, S.J.* Triterpenes from fruits of Rosalaevigata. Biochemical Systematics and Ecology, 2010, 38 (3)：457–459（IF=1.131）. 26. Yang, F., Zhang, H.J., Zhang, Y.Y., Chen, W.S., Yuan, H.L.* Lin, H.W.* A Hepatitis B Virus Inhibitory Neolignan from Herpetospermumcaudigerum.Chem Pharm Bull, 2010, 58 (3): 402-404（IF=1.698）. 27. Zhang, H.J., Yi, Y.H., Yang, F., Chen, W.S., Lin, H.W.* Sesterterpenes and a New Sterol from the Marine Sponge Phyllospongiafoliascens. Molecules, 2010, 15（2）：834-841（IF=1.738）. 28. Tang, H.F.* Cheng, G., Wu, J., Chen, X.L., Zhang, S.Y., Wen, A.D., Lin, H.W.* Cytotoxic asterosaponins capable of promoting polymerization of tubulin from the starfish Culcitanovaeguineae. Journal of Natural Products, 2009, 72 (2): 284-289（IF=3.159）. 29. Zhang, H.J., Tang, H.F., Yi, Y.H., Lin, H.W.* ScalaraneSesterterpenes from the Chinese Sponge Phyllospongiafoliascens. Helvetica ChimicaActa, 2009, 29 (4): 762-767（IF=1.435）. 30. Yang, F., Zhang, H.J., Liu, X.F., Chen, W.S., Tang, H.F.* Lin, H.W.* Oxygenated steroids from marine bryozoan Biflustragrandicella. Biochemical Systematics and Ecology, 2009, 37: 686-689（IF=1.131）.

主持4项国家863课题、3项国家科技重大专项、5项国家自然科学１金等课题22项。获“第六届施维雅青年药物化学家奖”（2003）、“上海药学科技二等奖”（2006）、“中国药学科学技术二等奖”（2007）、“上海医学科技二等奖”（2007）、“中华中医药学会科学技术二等奖”（2009）。近五年以通讯作者发表SCI收录论文28篇，影响因子5分以上3篇。申请发明专利18项，其中11项获专利授权

1995.091998.12 沈阳药科大学：师从姚新生院士和易杨华教授，从事海洋生物总合草苔虫抗肿瘤活性成分的分离筛选，获理学博士学位 日本神奈川大学：博士其间在日本神奈川大学釜野德明小组研修天然药物抗肿瘤活性物质的活性筛选和分离鉴定 1989.091992.07 第二军医大学药学院 硕士 研究常用中药免疫调节活性成分和作用机理 1985.091989.07 第二军医大学药学院 学士