姓名：杜艳芝 职称：研究员


个人简介：上海市辅助生殖与优生重点实验室副主任，上海交通大学医学院附属仁济医院生殖医学中心遗传实验室主任。中国医师协会生殖医学专业委员会精准辅助生殖研究学组委员，中国生理学会微生态专业委员会委员、上海市医学会分子诊断专科分会遗传学组副组长,上海市医学会生殖医学分会第三届委员会委员兼秘书等。近年负责/承担863计划、973计划、国家重点研发计划“生殖健康及重大出生缺陷防控研究”重点专项、国家自然科学基金面上项目和青年项目、中科院优秀青年科技专项、上海市科委项目等多项。曾获明治生命科学奖、上海市人才发展基金、上海市科技启明星称号等人才奖项。


研究方向：生殖遗传学、生殖内分泌学、药物靶点筛选和生物信息学


研究内容：主要从事女性生殖障碍疾病相关机制的研究。


多囊卵巢综合征（PCOS）发病机制和筛选分子靶点的研究；

排卵障碍性疾病患者肠道菌群谱及药物治疗对肠道菌群结构的影响；

环境和代谢因素在PCOS 亚型中的发病机制及互作研究。



代表性论文： (*Corresponding author)


1.Zhao J, Huang J, Geng X, Chu W , Li S, Chen ZJ, Du Y*.Polycystic Ovary Syndrome: Novel and Hub lncRNAs in the Insulin Resistance-Associated lncRNA– mRNA Network. Front. Genet. 2019 Aug 22;10:772. doi: 10.3389/fgene.2019.00772. eCollection 2019.


2.Wei Y, Lang J, Zhang Q, Yang CR, Zhao ZA, Du Y*, Sun Y*. DNA methylation analysis and editing in single mammalian oocytes. Proc Natl Acad Sci U S A. 2019 May 14;116(20):9883-9892. doi: 10.1073/pnas.1817703116. Epub 2019 Apr 22.


3.Zhu Y, Yin Q, Wei D, Yang Z, Du Y*, Ma Y. Autophagy in male reproduction. Syst Biol Reprod Med. 2019 Apr 24:1-8. doi: 10.1080/19396368.2019.1606361. [Epub ahead of print]


4.Di F, Liu J, Li S, Hong Y, Chen ZJ, Du Y*.Activating transcriptional factor 4 correlated with obesity and insulin resistance in polycystic ovary syndrome. Gynecol Endocrinol. 2019 Apr;35(4):351-355. doi: 10.1080/09513590.2018.1527307. Epub 2018 Nov 1.



5.Di F#, Liu J#, Li S#, Yao G, Hong Y, Chen ZJ, Li W, Du Y*.ATF4 contributes to ovulation via regulating COX2/PGE2 expression: a potential role of ATF4 in PCOS. Front Endocrinol (Lausanne). 2018 Nov 15;9:669. doi: 10.3389/fendo.2018.00669. eCollection 2018.


6.Li S, Zhai J, Liu J, Di F, Sun Y, Li W, Chen ZJ, Du Y*. Erythropoietin-producing hepatocellular A7 triggering ovulation indicates a potential beneficial role for polycystic ovary syndrome. EBioMedicine. 2018 Oct;36:539-552. doi: 10.1016/j.ebiom.2018.09.046.


7.Zhao J, Xu J, Wang W, Zhao H, Liu H, Liu X, Liu J, Sun Y, Dunaif A, Du Y*, Chen ZJ*. Long non-coding RNA LINC-01572:28 inhibits granulosa cell growth via a decrease in p27 (Kip1) degradation in patients with polycystic ovary syndrome. EBioMedicine. 2018 Oct;36:526-538. doi: 10.1016/j.ebiom.2018.09.043.


8.Wang Y, Zhang M, Chen ZJ, Du Y*. Resveratrol promotes the embryonic development of vitrified mouse oocytes after in vitrofertilization.In Vitro Cell Dev Biol Anim. 2018 Jun;54(6):430-438.


9.Zhu K, Li S, Liu J, Hong Y, Chen ZJ, Du Y*. The role of RAB5A in FSHR mediated signal transduction in human granulosa cells. Reproduction. 2018 Jun;155(6):505-514.


10.Xu X, Qin L, Tian Y, Wang M, Li G, Du Y, Chen ZJ*, Li W*. Family-based analysis of GGT1 and HNF1A gene polymorphisms in patients with polycystic ovary syndrome. Reprod Biomed Online. 2018 Jan;36(1):115-119.


11.Wei D, Zhang B, Shi Y, Zhang L, Zhao S, Du Y, Xu L, Legro RS, Zhang H, Chen ZJ.Effect of Preconception Impaired Glucose Tolerance on Pregnancy Outcomes in Women With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2017 Oct 1;102(10):3822-3829. doi: 10.1210/jc.2017-01294.


12.Li S, Zhai JY, Liu JS, Hong Y, Zhao WX, Zhao AM, Sun K, Du YZ*, Chen ZJ*. BMAL1 Facilitates Trophoblast Migration and Invasion via SP1-DNMT1/DAB2IP Pathway in Recurrent Spontaneous Abortion. Oncotarget. 2017 Sep 7;8(52):89451-89464.


13.Zhai J, Liu J, Zhao S, Zhao H, Chen ZJ, Du Y*, Li W*. Kisspeptin-10 inhibits OHSS by suppressing VEGF secretion. Reproduction. 2017 Jul 4.;154:355-362.


14.Zhai J, Liu J, Cheng X, Li S, Hong Y, Sun K, Chen ZJ, Du Y*, Li W*. Zinc finger gene 217 (ZNF217) Promoted Ovarian Hyperstimulation Syndrome (OHSS) through Regulating E2 Synthesis and Inhibiting Thrombospondin-1 (TSP-1). Sci Rep. 2017 Jun 12;7(1):3245. doi: 10.1038/s41598-017-03555-6.



15.Wei D, Shi Y, Li J, Wang Z, Zhang L, Sun Y, Zhou H, Xu Y, Wu C, Liu L, Wu Q, Zhuang L, Du Y, Li W, Zhang H, Legro RS, Chen ZJ. Effect of pretreatment with oral contraceptives and progestins on IVF outcomes in women with polycystic ovary syndrome. Hum Reprod. 2017 Feb; 32(2):354-361. doi: 10.1093/humrep/dew325. Epub 2016 Dec 19.


16.Xu X, Chen X, Zhang X, Liu Y, Wang Z, Wang P, Du Y, Qin Y, Chen ZJ. Impaired telomere length and telomerase activity in peripheral blood leukocytes and granulosa cells in patients with biochemical primary ovarian insufficiency. Hum Reprod. 2017 Jan;32(1):201-207. Epub 2016 Nov 11.


17.Zhou W, Fang F, Zhu W, Chen ZJ, Du Y, Zhang J. Bisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome. Int J Environ Res Public Health. 2016 Dec 27;14(1). pii: E18. doi: 10.3390/ijerph14010018.


18.Zhang J, Liu J, Zhu K, Hong Y, Sun Y, Zhao X, Du Y*, Chen ZJ. Effects of BMAL1–SIRT1-positive cycle on estrogen synthesis in human ovarian granulosa cells: an implicative role of BMAL1 in PCOS. Endocrine. 2016 Aug;53(2):574-84.


19.Tian Y, Zhao H, Chen H, Peng Y, Cui L, Du Y, Wang Z, Xu J, Chen ZJ. Variants in FSHB Are Associated With Polycystic Ovary Syndrome and Luteinizing HormoneLevel in Han Chinese Women. J Clin Endocrinol Metab. 2016 May;101(5):2178-84. doi: 10.1210/jc.2015-3776. Epub 2016 Mar 3.


20.Zhang Q, Liu D, Zhang M, Li N, Lu S, Du Y*, Chen ZJ. Effects of brain-derived neurotrophic factor on oocyte maturation and embryonic development in a rat model of polycystic ovary syndrome. Reprod Fertil Dev. 2016 Oct;28(12):1904-1915. doi: 10.1071/RD15131.