姓名：张丛 职称：教授


个人简介：张丛， 博士，教授，博士生导师。2003年获中国科学院动物研究所博士学位，2003-2005在北京大学生命科学学院进行博士后研究，2009-2010年在加拿大蒙特利尔大学访问学者。2015年入选2015年度上交通大学医学院高峰学科—临床医学“临床专职科研队伍”。是多项国家自然科学基金项目、国家重点研发计划课题负责人，是国家优秀青年基金项目评审专家，科技部创新人才推进计划评审专家。


研究方向：生殖内分泌


研究内容：


1 卵泡发育、排卵、黄体化和闭锁过程中的分子调节机理


2 女性生殖与疾病的调控机理研究, 通过运用基因敲除及条件性基因敲除小鼠模型、小鼠卵巢移植、病人血浆和胎盘标本库分析，重点研究先兆子痫，复发性流产，不孕不育等重大妊娠疾病的发病机制及其调控途径。


代表性论文：


已在Nature Medicine, Hypertension, Theriogenology, Biology of Reproduction, Reproduction, Endocrine, Development Growth & differentiation, Stem Cell Development, Journal of Hypertension，Journal of Cellular Biochemistry，Journal of molecular endocrinology, Gynecological Endocrinology, Journal of Reproduction and Development, Reproductive Biology and Endocrinology等杂志上发表或接受第一及通讯作者论文36篇。 其中在“Nature Medicine”发表的文章（Nat Med. 2013;19:1061-1066），受到特别关注，该杂志同期为该研究成果配发了相关评论文章(commentary： Nat Med. 2013;19:968-969) 并录制了播客（podcast ）(网址：http://www.nature.com/multimedia/podcast/nm/nm-2013-08-06.mp3), Science 杂志也在8月将其选为编辑精选（EDITORS’CHOICE：Science 2013;341:823）加以评论。


1. Ma Jin, Yang Jieqiong, Lv Shijian, Sun Yun, Chen Zi-Jiang, Zhang Cong*. Dysfunction of BNIP3 in Decidua is Involved in the Pathogenesis of Preeclampsia. Journal of Hypertension. 2019. in press.


2. Shijian Lv, Na Wang, Jin Ma, Wei-Ping Li, Zi-Jiang Chen, Cong Zhang*. Impaired decidualization caused by downregulation of Circadian Clock Gene BMAL1 contributes to human recurrent miscarriage. Biology of Reproduction.2019 （101）1, July, 138–147.


3. Min Zheng, Gaoge Zuo, Jing Tong, Zi-Jiang Chen, Wei-Ping Li, Cong Zhang*. Intrafollicular melatonin concentration is elevated in patients with ovarian hyperstimulation syndrome (OHSS) and can serve as an important predictor of OHSS. Archives of Gynecology and Obstetrics. 2019. 2019 (299):1151–1158. https://doi.org/10.1007/s00404-018-4994-z.


4. Shijian Lv, Na Wang, Hong Lv, Jieqiong Yang, Jianwei, Liu, Wei-Ping Li*, Cong Zhang*, and Zi-Jiang Chen*. The Attenuation of Trophoblast Invasion Caused by the Downregulation of EZH2 is involved in the Pathogenesis of Human Recurrent Miscarriage. Molecular Therapy-Nucleic Acids. 2019 Mar 1;14: 377-387. doi: 10.1016/j.omtn.2018.12.011.


5. Shi Feifei#, Li Hua, Wang Enling, Chen Zi-Jiang, and Zhang Cong* Melatonin reduces 2-cell block via non-receptor pathway in mice. Journal of Cellular Biochemistry. 2018 Nov;119(11):9380-9393. DOI: 10.1002/jcb.27255.


6. Yang Jieqiong#, Zhang Yachao, Tong Jing, Lv Hong, Zhang Cong*, Chen Zi-Jiang*. Dysfunction of DDIT4 in the Decidua Is Relevant to the Pathogenesis of Preeclampsia. Biology of Reproduction. 2018, 98(6), 821-833. DOI: 10.1093/biolre/ioy038


7. Lv Hong#, Tong Jing, Yang Jieqiong, Lv Shijian, Li Wei-Ping*, Zhang Cong*, Chen Zi-Jiang*. Dysregulated Pseudogene HK2P1 May Contribute to Preeclampsia as a ceRNA for Hexokinase 2 by Impairing Decidualization. Hypertension. 2018; 71: 648-658.


8. Zhang Yachao#, Yang Jieqiong#, Lv Shijian, Zhao Dong-Qin, Chen Zi-Jiang*, Li Wei-Ping*, Zhang Cong*. Down regulation of decidual SP1 and p300 is associated with severe preeclampsia. Journal of molecular endocrinology. 2018 Feb; 60(2):133-143.


9. Liu Linlin#, Yang Man, Wang Naiqiang, Li Li, Chen Zi-Jiang and Zhang Cong*. New insights of subfertility among transplanted women: immunosuppressive drug FK506 leads to calcium leak and oocyte activation before fertilization. Journal of Cellular Biochemistry. 2018 Mar;119(3): 2964-2977.


10. Chang Xin-Lian#, Liu Lisheng, Wang Naiqiang, Chen Zi-Jiang and Zhang Cong*. The function of HDL and LDL in the maintenance of mouse ovarian steroid. Biology of Reproduction. 2017 Jan 1;97(6):862-872.


11. Tong Jing#, Zhao Weixiu, Lv Hong, Li Wei-Ping, Chen Zi-Jiang, Zhang Cong*. Transcriptomic profiling in human decidua of severe preeclampsia detected by RNA sequencing. Journal of Cellular Biochemistry. 2018. 119:607-615.（IF 3.085）


12. Zhang Kaiyue#, Zhong Wanxia, Li Wei-Ping *, Chen Zi-Jiang * and Zhang Cong*. miR-15a-5p levels correlate with poor ovarian response in human follicular fluid. Reproduction. 2017. Oct; 154(4):483-496.


13. Tong Jing#, Sheng Shile, Sun Yun, Li Huihui, Li Wei-Ping*, Zhang Cong* and Zi-Jiang Chen*. Melatonin levels in follicular fluid as markers for IVF outcomes and predicting ovarian reserve. Reproduction. 2017. Apr; 153(4):443-451.


14. Zhang Dongmei#, Chang Xinlian, Bai Jing, Chen Zi-Jiang, Li Wei-Ping, Zhang Cong*. The Study of Cyclooxygenase 2 in Human Decidua of Preeclampsia. Biology of Reproduction. 2016 Sep; 95(3):56: 1-8.


15. Wang Guiping#, Zhang Zhaohang#, Chen Cheng#, Zhang Yachao#, Zhang Cong*. Dysfunction of WNT4/WNT5A in deciduas: possible relevance to the pathogenesis of preeclampsia. Journal Hypertension. 2016. Apr;34(4):719-727


16. Guo Tao#, Zhang Liang, Cheng Dong, Liu Tao, An Liguo, Li Wei-Ping*, Zhang Cong*. Low-density lipoprotein receptor affects the fertility of female mice. Reproduction Fertility and Development. 2015; 27(8): 1222-1232.


17. Guo Cui#, Meng Xiaoqian, Bai Jing, Chen Cheng, Liu Tao, Liu Shuzhen, Zhang Cong*, Li Wei-Ping* Expression and localization of transcription factors SNAIL and SLUG in mouse ovaries and pre-implantation embryos. Cell Tissue Research. 2014; 358(2):585–595.


18. Zhang Cong#, Murphy Bruce D. Progesterone is critical to the development of mouse embryos. Endocrine. 2014; 46:615-623.


19. Zhang Ting#, Dai Pengyuan#, Cheng Dong, Zhang Liang, Chen Zi-Jiang, Meng Xiaoqian, Zhang Fumiao, Han Xiaoying, Liu Jianwei, Pan Jie, Yang Guiwen, Zhang Cong*. Obesity occurred in apolipoprotein E knockout mice has mild effects on murine fertility. Reproduction. 2014; 147 :141–151.


20. Zhang Cong#, Large Michael J, Duggavathi Raj, DeMayo Francesco J, Lydon John P, Schoonjans Kristina, Kovanci Ertug and Murphy Bruce D. Liver receptor homolog-1 is essential for pregnancy. Nature Medicine. 2013;19（8）:1061-1066.