姓名：胡双纲 职称：助理研究员


个人简介：


2000.9-2004.7 山东师范大学 生命科学学院 获学士学位


2004.9-2011.1 中国科学院上海生命科学研究院生物化学与细胞生物学研究所


生物化学与分子生物学专业 获博士学位 导师：张永莲院士


2011.3-至今 上海交通大学医学院附属仁济医院生殖医学科 助理研究员


上海市医学会生殖医学分会第二届青年委员会委员，上海市中西医结合学会生殖医学实验室学组委员。作为项目负责人承担国家自然科学基金青年基金和面上项目各一项，发表SCI收录论文20余篇。曾受邀为Journal of Clinical Endocrinology & Metabolism，Asian Journal of Andrology，Andrology以及Oncotarget等杂志审稿。


研究方向： 辅助生殖


研究内容：1 配子发生成熟的分子机制2 子宫内膜容受性建立和维持的分子机制


代表性论文：


Shuanggang Hu*#, Ajuan Liang*, Guangxin Yao*, Xiangqi Li, Mei Zou, Jianwei Liu, Yun Sun#. The dynamic metabolomic changes throughout mouse epididymal lumen fluid potentially contribute to sperm maturation. Andrology; 2018; 6(1):247-255. (Co-corresponding author)

Guangxin Yao, Shuanggang Hu, Lu Yu, Yanfei Ru, Charlie Degui Chen, Qiang Liu, Yonglian Zhang. Genome-wide mapping of in vivo ERα binding sites in male mouse efferent ductules. Endocrinology; 2017; 158(11):3724-3737.

Shuanggang Hu, Guangxin Yao, Yang Wang, Haijing Xu, Xiaowei Ji, Yaqiong He, Qinling Zhu, Zijiang Chen, Yun Sun. Transcriptomic changes during the pre-receptive to receptive transition in human endometrium detected by RNA-Seq. Journal of Clinical Endocrinology and Metabolisom; 2014; 99(12):E2744-53. doi: 10.1210/jc.2014-2155

Shuanggang Hu, Xiangqi Li, Chunhua Tang, Yun Sun, Yonglian Zhang. Isolation and characterization of detergent-resistant membranes from rat spermatozoa. Asian Journal of Andrology; 2014; 16:790-791; doi: 10.4103/1008-682X.132979

Shuanggang Hu, Mei Zou, Guangxin Yao, Wubin Ma, Qinling Zhu, Xiangqi Li, Zijiang Chen, Yun Sun. Androgenic regulation of beta-defensins in the mouse epididymis. Reproductive Biology and Endocrinology; 2014; 12:76. doi:10.1186/1477-7827-12-76

Shuanggang Hu, Guangxin Yao, Xiangqi Li, Zijiang Chen, Yun Sun. Androgen receptor binding sites identified in mouse testis. Acta Biochimica et Biophysica Sinica; 2013; 45(9):795-797.

Chunmei Wang*, Shuanggang Hu*, Yanfei Ru, Guangxin Yao, Wubin Ma, Yihua Gu, Chen Chu, Shoulin Wang, Zuomin Zhou, Qiang Liu, Yuchuan Zhou, Yonglian Zhang. Different effects of androgen on the expression of Fut1, Fut2, Fut4 and Fut9 in male mouse reproductive tract. International Journal of Molecular Sciences; 2013; 14(11):23188-202. (* Co-first author)

Wubin Ma, Shuanggang Hu, Guangxin Yao, Shengsong Xie, Qiang Liu, Xinxing Gao, Jun Zhang, Xingxu Huang, Yonglian Zhang. An androgen-androgen receptor-miR-29a regulatory circuitry in mouse epididymis. Journal of Biological Chemistry; 2013; 11;288(41):29369-81

Li Ma, Heguo Yu, Zimei Ni, Shuanggang Hu, Wubun Ma, Chen Chu, Qiang Liu, Yonglian Zhang. Spink13, an Epididymis-specific Gene of the Kazal-type Serine Protease Inhibitor (SPINK) Family, Is Essential for the Acrosomal Integrity and Male Fertility. Journal of Biological Chemistry; 2013; 288(14):10154-65.

Shuanggang Hu, Han Du, Guangxin Yao, Yonglian Zhang. Molecular cloning and identification of mouse epididymis-specific gene mHong1, the homologue of rat HongrES1. Asian Journal of Andrology; 2012; 14(4):626-34

Zhaoliang Fei, Shuanggang Hu, Liqin Xiao, Jiabin Zhou, Hua Diao, Heguo Yu, Shubei Fang, Yicheng Wang, Yinghan Wan, Weigang Wang, Yuewei He, Chunmei Wang, Guojiang Xu, Zhugang Wang, Yonglian Zhang, Jian Fei. mBin1b transgenic mice show enhanced resistance to epididymal infection by bacteria challenge. Genes & Immunity; 2012;13(6):445-51

Shuanggang Hu, Guangxin Yao, Xiaojun Guan, Zimei Ni, Wubin Ma, Elizabeth M. Wilson, Frank S. French, Qiang Liu, Yonglian Zhang. Research resource: Genome-wide mapping of in vivo androgen receptor binding sites in mouse epididymis. Molecular Endocrinology; 2010; 24:2392-405. （Faculty of 1000高度评价）