姓名：姚广新 职称：研究实习员


个人简介：2016年毕业于中国科学院上海生命科学研究院生物化学与细胞生物学研究所，获得理学博士学位。同年7月就职于上海交通大学医学院附属仁济医院生殖医学中心，主要从事胚胎实验室辅助生殖工作及生殖医学相关的科学研究工作，致力于阐述生殖过程相关的生理及病理基础及分子机制，力求为改进胚胎培养方法及提高辅助生殖技术成功率提供科学依据。


研究方向：生殖生物学


研究内容：1. 子宫内膜容受性的建立及胚胎着床的分子机制


2. 精子发生及成熟的分子机制





代表性论文：


1、Di F#, Liu J#, Li S#, Yao G, Hong Y, Chen ZJ, Li W, Du Y*: ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS. Front Endocrinol (Lausanne) 2018, 9:669.


2、Hu S#*, Liang A#, Yao G#, Li X, Zou M, Liu J, Sun Y*, The dynamic metabolomic changes throughout mouse epididymal lumen fluid potentially contribute to sperm maturation. Andrology 2018, 6(1): 247-255.


3、Yao G#, Hu S, Yu L, Ru Y, Chen CD, Liu Q*, Zhang Y*: Genome-Wide Mapping of In Vivo ERalpha-Binding Sites in Male Mouse Efferent Ductules. Endocrinology 2017, 158(11):3724-3737.


4、Xu J#, Yao G, Ru Y, Xie S*: Expression of tamoxifen-inducible CRE recombinase in Lcn5-CreERT2 transgenic mouse caput epididymis. Molecular reproduction and development 2016.


5、Gao X#, Ma W#, Nie J#, Zhang C, Zhang J, Yao G, Han J, Xu J, Hu B, Du Y, Shi Q, Yang Z*, Huang X*, Zhang Y*: A G-quadruplex DNA structure resolvase, RHAU, is essential for spermatogonia differentiation. Cell death & disease 2015, 6:e1610.


6、Hu S#, Zou M, Yao G, Ma W, Zhu Q, Li X, Chen Z, Sun Y*: Androgenic regulation of beta-defensins in the mouse epididymis. Reproductive biology and endocrinology : RB&E 2014, 12:76.


7、Hu S#, Yao G, Wang Y, Xu H, Ji X, He Y, Zhu Q, Chen Z, Sun Y*: Transcriptomic changes during the pre-receptive to receptive transition in human endometrium detected by RNA-Seq. The Journal of clinical endocrinology and metabolism 2014, 99(12):E2744-2753.


8、Ma W#, Hu S, Yao G, Xie S, Ni M, Liu Q, Gao X, Zhang J, Huang X*, Zhang Y*: An androgen receptor-microrna-29a regulatory circuitry in mouse epididymis. The Journal of biological chemistry 2013, 288(41):29369-29381.


9、Hu S#, Yao G, Li X, Chen Z, Sun Y*: Androgen receptor binding sites identified in mouse testis. Acta biochimica et biophysica Sinica 2013, 45(9):795-797.


10、Xie S#, Xu J#, Ma W, Liu Q, Han J, Yao G, Huang X*, Zhang Y*: Lcn5 promoter directs the region-specific expression of cre recombinase in caput epididymidis of transgenic mice. Biology of reproduction 2013, 88(3):71.


11、Wang C#, Hu S#, Ru Y#, Yao G, Ma W, Gu Y, Chu C, Wang S, Zhou Z, Liu Q, Zhou Y, Zhang Y: Different effects of androgen on the expression of Fut1, Fut2, Fut4 and Fut9 in male mouse reproductive tract. International journal of molecular sciences 2013, 14(11):23188-23202.


12、Hu S#, Du H#, Yao G, Zhang Y*: Molecular cloning and identification of mouse epididymis-specific gene mHong1, the homologue of rat HongrES1. Asian journal of andrology 2012, 14(4):626-634.


13、Hu S#, Yao G, Guan X, Ni Z, Ma W, Wilson EM, French FS, Liu Q*, Zhang Y*: Research resource: Genome-wide mapping of in vivo androgen receptor binding sites in mouse epididymis. Molecular endocrinology 2010, 24(12):2392-2405.


14、胡双纲，姚广新，孙赟
。雄激素/雄激素受体对小鼠附睾Caveolin-1表达调控机制的研究。中华男科学杂志 2013,19(10) : 867-872


15、胡双纲，姚广新，赵晓明，孙赟，高玉平。人 HoxA10 基因真核表达载体构建和表达产物的鉴定。生殖与避孕 2013,33(6):383-386


16、姚广新，张怡轩，胡双纲。Intein介导的重组人AR DBD的原核可溶性表达、纯化及活性鉴定。中国生物工程杂志 2011, 30(4):7-11


17、张磊磊，由鹏飞，姚广新，侯爵，张怡轩
。新型抗结核分枝杆菌药物筛选模型的建立。微生物学杂志 2011,31(1):57-62